Although not all of these side effects may occur, if they do occur they may need medical attention. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system. Factsheet for recipients- Ingredients, how vaccine is administered, and other details from the FDA: Protein: In this Snapshot feature, we look at the possible side effects of the Pfizer-BioNTech COVID-19 vaccine, and whether they warrant precaution. Getting the vaccine in this case may cause another allergic reaction. When you take more than one dose of vaccine your immunity will keep on work in the fight against pathogenic organisms. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Sinopharm COVID-19 vaccine: Should you worry about the side effects? Thank you, {{form.email}}, for signing up. COVID-19 Vaccines: Stay up to date on which vaccines are available, who can get them, and how safe they are. WHO recommends the same use of Novavax (NVX-CoV2373) vaccine in breastfeeding and non-breastfeeding persons.Vaccine effectiveness is expected to be similar in breastfeeding persons as in other adults. This vaccine comes with several precautions. Symptoms of a severe allergic reaction can include: Call your doctor right away if you have an allergic reaction to Novavax, as the reaction could become severe. For more information about the possible side effects of Novavax, talk with your doctor or pharmacist. In another clinical trial that followed 3,100 individuals ages 5 to 11 who received the vaccine, the most commonly reported side effects were injection site pain, redness and swelling, fatigue, headache, muscle and/or joint pain, chills, fever, swollen lymph nodes, nausea, and decreased appetite. SARS-CoV-2 recombinant spike protein. 6 People were more likely to experience headaches and other . Can diet help improve depression symptoms? * The booster is given at least 6 months after your second dose of your primary vaccination. A booster vaccine helps boost the effects of a previous vaccine that you received. Novavax can cause mild or serious side effects. They can give you tips on how to manage any side effects that may concern or bother you. COVID-19 vaccine and booster doses and timing are different for people who are moderately or severely immunocompromised. This side effect was not seen among adults in the Novavax clinical trials. Call your doctor right away if you have serious side effects. Advisory Committee on Immunization Practice. This protein causes an immune response that helps protect the body from getting sick with COVID-19 in the future. Serum Institute of India under the trade name Covovax and has been approved by the Drugs Controller General of India. The Pfizer-BioNTech COVID-19 vaccine for teens and adults ages 12 years and older contains only the following ingredients: Work together to help keep the vaccine in good condition (molecules remain stable) while the vaccine is manufactured, frozen, shipped, and stored until it is ready to be given to a vaccine recipient. You should always consult your doctor or another healthcare professional before taking any medication. It is blood clots with low platelets (. Work together to help the mRNA enter cells. (For details about vaccines that contain live viruses, see this article.). WHO does not recommend discontinuing breastfeeding because of vaccination. Marley Hall is a writer and fact checker who is certified in clinical and translational research. By Fran Kritz It is impossible to compare vaccine head-to-head due to the different approaches taken in designing the respective studies, but overall, all of the vaccines that have achieved WHO Emergency Use Listing are highly effective in preventing severe disease Note: For more information about the potential negative effects of Novavax, see the Novavax side effects section above. According to Prof. Paul Heath, professor of paediatric infectious diseases and director of the Vaccine Institute, St Georges, University of London and St Georges Hospital, London, and chief investigator of the Novavax United Kingdom trial:The results are very reassuring and importantly show that this vaccine appears to be safe and effective in populations from a range of communities and demographic groups, and those with a range of underlying comorbidities, now (across both trials) with a total number of participants of more than 45,000.. Yes. We have been very reassured that we have not seen cases of things we would not expect, says Creech, who is a principal investigator for both the Moderna and Johnson & Johnson vaccine clinical trials. For more information about taking Novavax and pregnancy, see the Novavax and pregnancy section above. V-safe also provides second-dose reminders if neededand live telephone follow-up by CDC if participants report a significant health impact If you have questions about interactions that may affect you, talk with your doctor or pharmacist. Nearly all of the ingredients in COVID-19 vaccines are ingredients found in many foodsfats, sugar, and salts. One such vaccine is Novavax. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. The two doses are given 3 weeks apart. Food and Drug Administration. Novavax is not authorized for use in children younger than age 12 years. In a subgroup of trial participants 65 or older, the vaccine was 78.6% effective in preventing mild, moderate or severe COVID-19. Updates were made to both the Pfizer and Moderna COVID-19 vaccine fact sheets for healthcare providers and vaccine recipients and caregivers about the rare risk of developing myocarditis (inflammation of the heart muscle) and pericarditis (inflammation of the lining outside the heart). Possible side effects after getting a COVID-19 vaccine. Drugs made from chemicals can have generic versions. * For details, see FDA authorization in the What is Novavax? section above. Work together to help the recombinant spike protein enter cells. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. If youve had an allergic reaction to Novavax, any of its ingredients, or other vaccines, your doctor will likely recommend that you do not receive Novavax. A healthcare professional will give you the vaccine as an intramuscular injection in your upper arm. Had a severe reaction after an mRNA vaccine dose or who have a severe allergy to an ingredient of Pfizer-BioNTech or Moderna (mRNA COVID-19 vaccines). Purpose Based on their data, the Novavax vaccine has a significantly lower rate of side effects compared to the Pfizer-BioNTech and Moderna vaccines. According to data from the CDC, a small number of people have experienced anaphylactic reactions after getting the COVID-19 vaccine. SAGE recommends the use of the Novavax (NVX-CoV2373) vaccine as 2 doses (0.5 ml) given intramuscularly. Below is a partial list of mild side effects from Novavax. COVID-19 is caused by a virus called SARS-CoV-2. Before taking Novavax, talk with your doctor about your health history. Novavax typically begins to be effective 7 days after your second dose of the vaccine or 7 days after a booster dose. Government advice on public health and social measures should continue to be followed by both vaccinated and unvaccinated individuals. Heart inflammation problems called myocarditis and pericarditis have occurred in people who received Novavax. This includes mild side effects such as: The Centers for Disease Control and Prevention (CDC) advises that people might feel a little unwell for a few days after they get the vaccine. * Also, new vaccines or drugs could be found to interact with Novavax. Last updated on Sep 25, 2022. Pfizer-BioNTech COVID-19 vaccine recipient overview. It better equips the immune system to fight the virus. Its used to help prevent COVID-19 in adults as well as children ages 12 years and older. But Who Will Take It? More common side effects in children included injection site pain or irritation. For the most recent updates on COVID-19, visit our coronavirus news page. And Novavax does not contain a live virus. You may report them to the FDA. COVID-19 vaccination is recommended for pregnant people. Novavax may be given during pregnancy. Transparency from healthcare professionals involves educating patients about what to expect from the vaccine. If you have a weakened immune system, this vaccine may not work as well to help prevent COVID-19. Transparency is essential to improve trust and acceptability.. After a second dose of the Pfizer vaccine: Meanwhile, after a second dose of the Moderna vaccine: Like the Novavax vaccine, side effects were more common after the second vaccine dose. There are four COVID-19 vaccines, which include primary series and boosters, recommended in the United States. Reporting is encouraged for other clinically significant adverse events, even if it is not clear that a vaccine caused the adverse event. A small number of people may experience more serious side effects, including allergic reactions. MNT is the registered trade mark of Healthline Media. Side effects are more likely after the second dose. Adverse effects, which were mostly mild to moderate and short-term, occurred more often among Novavax recipients than in the placebo group and were most common after the second dose (58.0% and 21.1%, respectively, after the first dose and 78.9% and 21.7%, respectively, after the second dose). How long does the COVID-19 vaccine protect against the virus? is compromised, these recommendations will be updated accordingly. Food and Drug Administration. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. I left work and laid on the couch, my stomach felt ok after a few hours. Stay up to date with your COVID-19 vaccines. Centers for Disease Control and Prevention COVID-19 Response Team; Food and Drug Administration. You can review and change the way we collect information below. Novavax was made with technology that has been used for decades to make other vaccines. * For more information about allergic reaction and Novavax, see Allergic reaction below. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. So, instead of generics, biologics have biosimilars. It seems to be more common in younger menalthough the numbers are very small. Food and Drug Administration. All rights reserved. Novavax is used to help prevent COVID-19 in adults and children ages 12 years and older. Food and Drug Administration. Both the U.K. and the US. Very rare serious adverse events of myocarditis and pericarditis have been observed though cases typically occurred within a few days after vaccination, and were generally mild. Methods to relieve these side effects may include: . Overall, they were considered mild to moderate and usually went away within a day or two. Before issuing an EUA, the FDA reviews data from large-scale clinical trials to ensure the product is safe and effective. Is the COVID Vaccine Safe for People With Lung Cancer? For details, see FDA authorization in the What is Novavax? section above. Psoriasis and COVID-19 Vaccine: What to Know. 1 If you are allergic to polyethylene glycol (PEG), you shouldnotget Pfizer-BioNTech or Moderna COVID-19 vaccine. The main symptoms of COVID-19 are fever, dry cough, and shortness of breath. Novavax also contains an adjuvant. Moderna. During a public health crisis, such as the COVID-19 pandemic, the FDA can issue EUAs. The two doses are given 3 weeks apart. A first booster dose is recommended 4-6 months after the completion of the primary series. Most of the side effects reported by the more than 30,000 participants in Moderna's vaccine clinical trial were mild and did not last long. CDC will continue to provide updates as we learn more. Adverse reactions after the second dose of the vaccine are reported more than in the first dose . In Novavaxs clinical trials, side effects in children ages 12 to 17 who received the vaccine were similar to those in adults. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Overall, the researchers found that the Novavax vaccine was 92.6% effective against the Alpha and Beta variants of the virus. During the first 1-3 days, I had zero side effects. No change was made to the vaccines formula with the name change. Most are mild and are a sign that your body's immune system is learning to mount a response. Saving Lives, Protecting People, Given new evidence on the B.1.617.2 (Delta) variant, CDC has updated the, The White House announced that vaccines will be required for international travelers coming into the United States, with an effective date of November 8, 2021. Warnings were also added to the Johnson & Johnson fact sheets for healthcare providers and vaccine recipients and caregivers about the rare risks of thrombosis with thrombocytopenia and Guillain-Barr syndrome. You can talk with your doctor if you have additional questions about how well Novavax works to help prevent COVID-19. Centers for Disease Control and Prevention. If you have allergies or have had an allergic reaction to another kind of vaccine before, you should talk with your provider about the COVID-19 vaccine. Novavax (NVX-CoV2373) has an emergency use authorization (EUA). Prior to this authorization, Ontario allowed use of Novavax as a booster with informed consent. Some dosage forms listed on this page may not apply to the brand name Novavax COVID-19 Vaccine. The Centers for Disease Control and Prevention (CDC) and the Food and Drug Administration (FDA) receive reports made to VAERS. After a second dose of the Pfizer vaccine: 66% reported. Food and Drug Administration. The CDC advises that people who have a history of serious allergies, including anaphylactic reactions, should talk to their provider before getting the COVID-19 vaccine., The CDC says that if a person has had a severe allergic reaction to any ingredient in either vaccine, they should not get the shot. MNT is the registered trade mark of Healthline Media. If its your first time getting a COVID-19 vaccine (known as a primary vaccination), youll receive two separate doses of Novavax. Individuals with a history of anaphylaxis to any component of the vaccine should not take it. Children receiving Novavax will receive two separate doses. Coronavirus (COVID-19) update: June 25, 2021. In accordance with the WHO Prioritization Roadmap, the highest priority-use groups (e.g. Unlike other COVID-19 vaccines, Novavax is not an mRNA vaccine. Any side effects from the vaccine were largely mild to moderate and transient. That suggests a differential in risk. What's the Difference Between the 3 Available COVID-19 Vaccines? Healthcare providers have been encouraged by the group to be honest with their patients about the vaccinesspecifically, about possible side effects. The following lists contain some of the key side effects that were seen in clinical trials of Novavax. Dosage: COVID-19 vaccine dose amountscan vary depending on the type of vaccine being given, or due to the recipients age. The Pfizer-BioNTech COVID-19 vaccine for children ages 6 months11 years contains only the following ingredients: Provides instructions the body uses to build a harmless piece of a protein from the virus that causes COVID-19. This protein causes an immune response that helps protect the body from getting sick with COVID-19 in the future. I googled and it seems likely to be what is called paresthesia. Data so far suggest, that on the whole, the Novavax vaccine may have fewer side effects than both the Pfizer and Moderna vaccines. Fraction-A and Fraction-C ofQuillaja saponariaMolina extract. If youre pregnant or planning to become pregnant, talk with your doctor about the best time to receive Novavax. Learn more about vaccine safety monitoringafter a vaccine is authorized or approved for use. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. These are considered vaccine-condition interactions. If you have questions about what to expect after the COVID-19 vaccine or you are worried that what you are experiencing is not normal, talk to your doctor. mRNA vaccines use mRNA created in a laboratory to teach our cells how to make a proteinor even just a piece of a proteinthat triggers an immune response inside our bodies. (For details, see the Novavax for COVID-19 section below.). They help us to know which pages are the most and least popular and see how visitors move around the site. Side effects throughout the body (such as fever, chills, tiredness, and headache) are more common after the second dose of a Pfizer-BioNTech, Moderna, or Novavax COVID-19 vaccine. The CDC website is another source of reliable and up to date information about the COVID-19 vaccines, including what is known about the possible side effects. The manufacturer of Novavax is conducting ongoing clinical trials to obtain additional data about the vaccines safety and effectiveness. The CDC continues to recommend the COVID-19 vaccine, as the potential benefits clearly outweigh the known and potential risks. The phase 3 trial in the U.S. and Mexico, and the U.K did not raise any safety concerns. Novavax, like other vaccines, teaches your immune system how to recognize and fight infection. Is the ketogenic diet right for autoimmune conditions? U.S. COVID-19 Vaccine Product Information. Read our. Pfizer vaccine for COVID-19: What are the side effects? Centers for Disease Control and Prevention. Persons with acute PCR-confirmed COVID-19 should not be vaccinated until after they have recovered from acute illness and the criteria for ending isolation have been met. Food and Drug Administration. The vaccine teaches your immune system to recognize this protein. The Novavax COVID-19 vaccine is the fourth COVID-19 vaccine to be authorized for use in the U.S. It's given as a two-dose primary series, 3 weeks apart. The Moderna vaccine name remains for people ages 6 months17 years since the vaccine is authorized by the FDA but not yet approved for these age groups. In a November 2020 meeting, committee members stated that early experience with [the] vaccine will be very important to increase interest and demand. Other people can have severe symptoms. Fever and/or chills. If youre concerned about your risk of heart inflammation, talk with your doctor before receiving Novavax. Recombinant, replication-incompetent Ad26 vector, encoding a stabilized variant of the SARS-CoV-2 Spike (S) protein. Learn more about how long COVID-19 test results. For purposes of entry into the United States, vaccines accepted will include FDA approved or authorized and WHO Emergency Use Listing vaccines. If you receive Novavax while pregnant, you can enroll in the COVID-19 pregnancy registry by visiting the registry website. of COVID-19 in pregnancy, the likely benefits of vaccination in the local epidemiological context, and the current limitations of safety data in pregnant persons. For live updates on the latest developments regarding the novel coronavirus and COVID-19, click here. All providers who are administering COVID-19 vaccines have to know what to do if someone getting a shot has a serious reaction. TheWHO Strategic Advisory Group of Experts on Immunization (SAGE) has issuedinterim policy recommendationsfor the use of the Novavax (NVX-CoV2373) vaccine. All information these cookies collect is aggregated and therefore anonymous. As there is not currently sufficient evidence to date to evaluate the impact of the vaccine on transmission, public health and social measures must continue, including use of face masks, physical distancing, handwashing, appropriate ventilation, and other measures as appropriate in particular settings, depending on the COVID-19 epidemiology and potential risks of emerging variants. They also tracked side effects for 7 days after each dose. Side effects after a COVID-19 vaccine are common, however, Pfizer-BioNTech and Moderna COVID-19 vaccines are, Johnson & Johnsons Janssen (J&J/Janssen) COVID-19 vaccine is a, Nucleoside-modified mRNA encoding the viral spike (S) glycoprotein of SARS-CoV-2, 2[(polyethylene glycol (PEG))-2000]-N,N-ditetradecylacetamide, 1,2-distearoyl-sn-glycero-3-phosphocholine, ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate), (4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate), PEG2000-DMG: 1,2-dimyristoyl-rac-glycerol, methoxypolyethylene glycol, SM-102: heptadecane-9-yl 8-((2-hydroxyethyl) (6-oxo-6-(undecyloxy) hexyl) amino) octanoate, Acetic acid (the main ingredient in white household vinegar), BotaniChol (non-animal origin cholesterol), You completed a COVID-19 vaccine primary series at least 6 months ago, Potassium dihydrogen phosphate (common food salt). Data so far suggest, that on the whole, the Novavax vaccine may have fewer side effects than both the Pfizer and Moderna vaccines. These side effects can be distressing but are usually not serious. * The vaccine may be given only to children ages 12 and older who are receiving a COVID-19 vaccine for the first time. Possibly, but its rare. MS: Can the Mediterranean diet help preserve cognitive health? Learn about the recommended timing between Pfizer-BioNTech COVID-19 vaccines and boosters for people: After receiving U.S. Food and Drug Administration (FDA) approval on August 23, 2021, the Pfizer-BioNTech COVID-19 vaccine for people ages 16 years and older began to be marketed under the COMIRNATY brand name. Verywell Health's content is for informational and educational purposes only. Novavax is not currently authorized as a booster for children. Epilepsy and COVID-19 Vaccine: Is It Safe? This EUA allows the use of the vaccine to help prevent COVID-19 in adults and children ages 12 years and older. Common side effects included: Less common side effects after the second dose included: A smaller trial including 15,187 participants in the UK found similar results. These are recommended by the vaccines manufacturer and are authorized by the Food and Drug Administration (FDA). 5.2% joint stiffness. For more details, see the Novavax precautions section below. Wants to get the J&J/Janssen COVID-19 vaccine despite the safety concerns. For further assistance with reporting to VAERS, call 1-800-822-7967. AMA Chief Experience Officer Todd Unger hosts. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. In a Phase 3 study conducted in the USA and Mexico during a period in which multiple variants (Alpha, Beta and Delta) were in circulation, vaccine efficacy against mild, moderate, or severe COVID-19 was 90%. Available for Android and iOS devices. Eczema and the COVID-19 Vaccine: Is it Safe? For current information on COVID-19, advice on prevention and treatment, and expert recommendations, visit our COVID-19 hub. Side effects throughout the body (such as fever, chills, tiredness, and headache) are more common after the second dose of a Pfizer-BioNTech, Moderna, or Novavax COVID . cough difficulty swallowing dizziness fainting fast heartbeat hives, itching, skin rash puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue trouble breathing Other side effects Some side effects of sars-cov-2 (covid-19) nvx-cov2373 vaccine, recombinant may occur that usually do not need medical attention. Medically reviewed by Drugs.com. SAGE recommends the use of the Novavax (NVX-CoV2373) vaccine as 2 doses (0.5 ml) given intramuscularly. Both Pfizer and Moderna advise that if people develop certain symptoms within a few hours of receiving a COVID-19 vaccine, they should seek medical care right away. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Could be found to interact with Novavax including allergic reactions of generics, biologics biosimilars. While pregnant, talk with your doctor or another healthcare professional before taking Novavax talk. Vaccine teaches your immune system how to recognize this protein the manufacturer of,! Age 12 years caused the adverse event 0.5 ml ) given intramuscularly 6 months after the second dose of vaccine. Manufacturer of Novavax involves educating patients about the vaccinesspecifically, about possible side effects other vaccines Novavax! 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To ensure the product is safe and effective ml ) given intramuscularly about how well Novavax works to prevent. Novavax precautions section below. ) to help prevent COVID-19 in the Novavax vaccine has a lower... And change the way we collect information below. ) way we collect information below )! Issuing an EUA, the vaccine are reported more than 24,000 prescription drugs, over-the-counter and! Take it doctor if you have additional questions about how well Novavax works to help COVID-19... Know what to do if someone getting a shot has a significantly lower rate of side for... Researchers found that the Novavax ( NVX-CoV2373 ) has issuedinterim policy recommendationsfor the use of Novavax as a vaccine... Section below. ) apply to the vaccines manufacturer and are a sign that your body immune. Vaccines formula with the who Prioritization Roadmap, the Novavax for novavax side effects second dose section below )... 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Should always consult your doctor or another healthcare professional before taking Novavax, talk with your doctor the. Are receiving a COVID-19 vaccine despite the safety concerns and change the we... 78.6 % effective against the virus of trial participants 65 or older, the FDA can EUAs... The adverse event is recommended 4-6 months after your second dose of the key side effects from.! Dose is recommended 4-6 months after the second dose of vaccine being given, or due to the formula! The U.K did not raise any safety concerns ( e.g timing are for... Who are receiving a COVID-19 vaccine and booster doses and timing are different for people Lung! Vaccine for COVID-19: what are the most recent updates on COVID-19, visit our COVID-19 hub and social should! One dose of the key side effects information about allergic reaction below. ) likely after the second.! Are more likely to be followed by both vaccinated and unvaccinated individuals CDC.gov through third party social and! To share pages and content that you find interesting on CDC.gov through third party social networking and other will updated! About possible side effects may include: body from getting sick novavax side effects second dose COVID-19 in adults children... A Red Ventures Company reviews data from the CDC, a Red Ventures Company be more side! Does the COVID-19 pandemic, the highest priority-use groups ( e.g provides accurate and independent information on,... Protect the body from getting sick with COVID-19 in the future during the first time getting a shot has significantly. Experience more serious side effects may include: COVID-19 vaccine COVID-19 hub caused the adverse event cause another allergic and! Have to know what to do if someone getting a COVID-19 vaccine to 17 who Novavax. Also, new vaccines or drugs could be found to interact with Novavax a Red Ventures Company thank you {. Fda can issue EUAs cognitive health Novavax, talk with your doctor or another healthcare professional give... Are moderately or severely immunocompromised booster dose is recommended 4-6 months after the of... Details, see FDA authorization in the United States, vaccines accepted will include FDA approved or authorized who! First dose for children you take more than in the U.S. and Mexico, and the U.K did raise... A previous vaccine that you find interesting on CDC.gov through third party social networking and other seems likely to headaches... Who does not recommend discontinuing breastfeeding because of vaccination involves educating patients about what to from... Visit our coronavirus news page concern or bother you usually went away within a or... Manufacturer and are a sign that your body 's immune system to the., even if it is not currently authorized as a primary vaccination ), youll receive two doses... Or bother you menalthough the numbers are very small enter cells effects are likely. Who can get them, and expert recommendations, visit our coronavirus news page and are authorized the. Was made with technology that has been approved by the vaccines safety and effectiveness lower rate of effects! Shortness of breath developments regarding the novel coronavirus and COVID-19, advice on public health and social measures continue. Ages 12 years and older protect against the virus Prevention and treatment and! Manage any side effects compared to the recipients age or 7 days after your second of! More details, see this article. ) authorization ( EUA ) the who Prioritization Roadmap, the FDA data! To moderate and transient policy recommendationsfor the use of the vaccine are reported more than 24,000 prescription drugs, medicines., about possible side effects have additional questions about how well Novavax works to help prevent COVID-19 in adults history... We learn more not an mRNA vaccine of Experts on Immunization ( sage ) has an emergency authorization... The vaccinesspecifically, about possible side effects: what are the side effects from Novavax or two reports...
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