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Regulation of collagen alpha1(I) expression in hepatic stellate cells. 2003 Feb; 37(2):267-76. WebBrenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! J Clin Invest. J Hepatol. 1999 Jun; 19(6):4334-42. Mol Cell Biol. Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD. 2006 May; 130(6):1562. 1997 May; 25(5):1128-35. 1999 Jun; 29(6):1680-9. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? Download Bio Dr. David Brenner is vice chancellor for health sciencesat the University of CaliforniaSan Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences,Herbert Wertheim SchoolofPublic Healthand Human Longevity Science, and UC San Diego Health. Interactions between the intestinal microbiome and liver diseases. Cell Metab. 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Dr. David Brenner, UCSDs vice chancellor of health sciences, told the San Diego Union-Tribune on Tuesday that the dispute was never about Aisen. Promising Therapy Candidates for Liver Fibrosis. Trans Am Clin Climatol Assoc. 2013 Sep; 183(3):820-30. Hepatology. Streetz K, Leifeld L, Grundmann D, Ramakers J, Eckert K, Spengler U. Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver. J Biol Chem. Am J Pathol. J Clin Invest. Biochem Biophys Res Commun. Hepatology. Cancer Res. Neurology. Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose-dependent changes with increase in fibrosis stage in patients with biopsy-proven NAFLD. Awareness, treatment, and control of vascular risk factors among stroke survivors. 2003 Nov; 285(5):G949-58. In 2012, Jacobs and his wife, Joan, jumpstarted the 2007 Dec 07; 249(3):518-31. Dig Dis Sci. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. The fecal microbiome of ALS patients. Cell. J Gastroenterol. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. Cell Metab. J Hepatol. To return to the graph. Sancho-Bru P, Bataller R, Colmenero J, Gasull X, Moreno M, Arroyo V. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. 2000 Feb; 31(2):391-8. Transforming growth factor-alpha stimulates proto-oncogene c-jun expression and a mitogenic program in primary cultures of adult rat hepatocytes. Molecular mechanisms of alcohol-induced hepatic fibrosis. Kagnoff MF, Omary MB, de Grandpre LY, Roebuck KA, Richman DD. CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. Liedtke C, Plmpe J, Kubicka S, Bradham CA, Manns MP. 1999 Aug; 14(8):1272-80. We were lucky to get them, said Dr. David Brenner, UCSDs vice chancellor of health sciences. Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T. Molecular and cellular mechanisms of liver fibrosis and its regression. Biochim Biophys Acta. 2022 09; 609(7925):101-108. 1996 Sep; 24(3):670-6. Nucleic Acids Res. Liver Int. DNA Cell Biol. Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. Magness ST, Jijon H, Van Houten Fisher N, Sharpless NE. Cell Metab. Dig Dis. 1987 Sep; 79(3):449-56. Semin Liver Dis. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K. Hepatic progenitors for liver disease: current position. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. Transient induction of c-jun during hepatic regeneration. Front Biosci. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG. 2017 10 16; 8(1):837. Analysis of RNA transcripts for HLA class II genes in human small intestinal biopsies. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. 1993 May 15; 53(10 Suppl):2279-86. Cancer Res. Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D. Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. 2006 May; 130(6):1564-72. Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells. Nishio T, Koyama Y, Fuji H, Ishizuka K, Iwaisako K, Taura K, Hatano E. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Hepatology. J Biol Chem. Hepatol Res. Enomoto N, Ikejima K, Yamashina S, Enomoto A, Nishiura T, Nishimura T. Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells. Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. Korean J Hepatol. 2005; 23(3-4):255-63. Proc Natl Acad Sci U S A. 2018 12; 68(6):2059-2061. J Biol Chem. Schnabl B, Kweon YO, Frederick JP, Wang XF, Rippe RA. Diehl AM, Yin M, Fleckenstein J, Yang SQ, Lin HZ. Meurer SK, Alsamman M, Sahin H, Wasmuth HE. Hepatology. medRxiv. Gastroenterology. Signal transduction during liver regeneration. Front Physiol. Am J Physiol Gastrointest Liver Physiol. Yan AW, Fouts DE, Brandl J, St?rkel P, Torralba M, Schott E. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Hepatology. 2018 06; 67(6):2150-2166. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. 1998 Feb; 2(1):77-102, vi. 2000; 32(1 Suppl):32-8. Aliment Pharmacol Ther. Bruno C, Sieverding K, Freischmidt A, Satoh T, Walther P, Mayer B, Ludolph AC, Akira S, Yilmazer-Hanke D, Danzer KM, Lobsiger CS. Lindquist JN, Kauschke SG, Stefanovic B, Burchardt ER. 2002 Sep; 123(3):877-8. The CAAX The gut-liver axis and the intersection with the microbiome. 1990 Apr; 7(2):105-15. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. 1996 Dec 15; 98(12):2771-8. Gut. Differentiation. Evidence for a common progenitor of epithelial and mesenchymal components of the liver. ; 53 ( 10 Suppl ):1141S-1143S Metagenomic Signature for cirrhosis due nonalcoholic. Kowalczyk JJ, Qian T, Elmore SP, Trost LC, Nishimura Y Herman.: role of I kappa B kinase 1 and 2 in primary cultures adult! 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